Does EBOO Therapy Work for Long COVID? Clinical Evidence & Treatment Guide

Long COVID continues to affect millions globally in 2026, with approximately 36% of COVID-19 survivors experiencing persistent symptoms months after initial infection. For many, the fatigue, brain fog, and exercise intolerance disrupt professional performance and quality of life—despite trying rest, supplements, and conventional medical approaches.

When standard treatments fail to address the cellular dysfunction underlying post-viral syndromes, some patients turn to advanced therapeutic protocols. Extracorporeal Blood Oxygenation and Ozonation (EBOO therapy)—a systemic ozone treatment that processes the entire blood volume—has emerged as a promising intervention for complex Long COVID cases.

Recent clinical research demonstrates encouraging outcomes: research published in Medical Gas Research showed that 67% of ozone-treated Long COVID patients recovered normal function across a 100-patient cohort. Additional clinical studies examining systemic ozone therapy for post-viral conditions have reported significant improvements in fatigue, cognitive function, and exercise tolerance, suggesting EBOO therapy represents a promising intervention for complex Long COVID cases.

This article examines the clinical evidence supporting EBOO therapy for Long COVID, explains the treatment mechanism, and provides guidance on whether this advanced protocol may support your recovery journey.

Understanding Long COVID: Why Standard Treatments Often Fall Short

Long COVID describes persistent symptoms lasting three months or longer after acute COVID-19 infection. Unlike the initial viral illness, Long COVID presents as a complex post-viral syndrome characterised by crushing fatigue, cognitive impairment, exercise intolerance, and disrupted sleep patterns that fundamentally alter daily functioning.

The mechanisms driving Long COVID symptoms operate at the cellular level. Mitochondrial impairment reduces ATP production—the energy currency powering every cell. Think of it like a car running on a depleted battery: the engine works, but can't sustain normal performance. Chronic oxidative stress and inflammation create self-perpetuating cycles of cellular damage. Immune dysregulation leaves the body stuck in high alert mode, while microvascular dysfunction prevents adequate oxygen delivery to tissues.

Standard medical advice for Long COVID typically includes rest, gradual activity pacing, and basic nutritional supplementation. While these strategies help manage symptoms, they don't directly address the cellular dysfunction driving the condition. Rest allows symptom management but doesn't restore mitochondrial function or modulate oxidative stress. Rehabilitation programs fail when underlying mitochondrial capacity remains impaired. This gap creates the context in which patients seek advanced therapeutic options that address oxidative stress, immune modulation, and mitochondrial function at cellular level.

How EBOO Therapy Addresses Long COVID at the Cellular Level

EBOO represents an advanced form of ozone therapy that processes your entire blood volume through a specialised filtration system during a single 60-90 minute session. Unlike minor autohemotherapy (MAH)—which treats small volumes of blood—EBOO processes all blood components through a dialysis-like system where they're exposed to precisely calibrated medical ozone before being returned to circulation.

Medical-grade ozone (O₃) functions as an oxidative stress modulator through hormesis—controlled, mild stress triggers beneficial adaptive responses. When medical ozone contacts blood components, it creates controlled oxidative exposure that paradoxically reduces chronic oxidative stress over time by upregulating endogenous antioxidant systems: glutathione, superoxide dismutase, and catalase production increases in response. A 2025 study on systemic ozone therapy for post-COVID asthenia demonstrated glutathione peroxidase levels increased 1.7-fold following treatment protocols.

EBOO's effects on Long COVID operate through multiple mechanisms: immune system recalibration by modulating inflammatory cytokine production, mitochondrial function enhancement through supporting biogenesis and improved ATP production, improved microcirculation by enhancing red blood cell deformability and oxygen release to tissues, and oxidative stress reduction through training antioxidant systems. For Long COVID patients trapped in cycles of chronic inflammation and oxidative damage, this recalibration of cellular stress responses represents a pathway toward sustainable recovery.

Clinical Evidence: EBOO and Ozone Therapy for Long COVID Recovery

The clinical research examining ozone therapy for Long COVID has evolved rapidly through 2024-2025, with multiple independent studies demonstrating consistent positive outcomes.

Research published in Medical Gas Research evaluated 100 Long COVID patients receiving ozone therapy, finding that 67% recovered normal function following treatment protocols. This study provides crucial evidence that systemic ozone therapy supports recovery in patients experiencing persistent post-viral symptoms, with outcomes measured through standardised functional assessments demonstrating measurable improvements in fatigue, cognitive function, and exercise tolerance.

A 2024 randomised controlled trial examining ozone therapy for Long COVID demonstrated a 71% response rate in the treatment group compared to 45% in controls (p=0.0325), representing statistically significant improvement. Patients showed measurable gains in pulmonary function, six-minute walk distance, and immune markers.

The most recent research published in 2025 examining systemic ozone therapy for post-COVID fatigue syndrome reported remarkable findings: 95% of patients achieved complete or near-complete resolution of post-COVID asthenia, fatigue scores improved dramatically from 81.9 to 20.5—a 74.4% reduction, cognitive function improved measurably on standardised MoCA scale assessments, zero adverse events were reported across the study cohort, and biochemical analysis showed glutathione peroxidase increased 1.7-fold.

Multiple independent studies show consistent positive outcomes across symptom relief, functional capacity, and biochemical markers. The safety profile appears favourable in clinical research settings, with recent studies reporting zero adverse events when EBOO is administered under proper medical protocols. Response rates ranging from 67-95% suggest many—though not all—patients benefit from ozone therapy protocols.

EBOO vs Other Long COVID Therapies: Understanding Your Options

IV vitamin therapy provides direct nutrient delivery, supporting cellular function through micronutrient optimisation. EBOO operates at a different level, addressing cellular dysfunction through oxidative modulation and immune system recalibration. Many patients combine both approaches strategically: IV vitamins for micronutrient optimisation alongside EBOO for mitochondrial and immune system support.

NAD+ therapy supports mitochondrial function by supplying nicotinamide adenine dinucleotide essential for ATP generation. EBOO modulates oxidative stress and immune balance through different mechanisms. While NAD+ provides biochemical fuel for mitochondrial function, EBOO creates conditions supporting mitochondrial biogenesis. Some protocols combine NAD+ infusions with EBOO therapy for comprehensive mitochondrial support.

EBOO therapy demonstrates particular relevance for patients with severe, persistent symptoms lasting six months or longer. When conventional approaches have plateaued without adequate relief, treatments targeting oxidative stress and immune dysregulation offer different therapeutic leverage. Our medical team personalises combination protocols based on individual assessment, considering symptom severity, treatment history, and individual treatment goals.

What to Expect: EBOO Treatment Protocol for Long COVID

EBOO therapy begins with comprehensive health history review conducted by our qualified medical professionals. We explore your symptom timeline, treatments already attempted, current functional limitations, and treatment goals. Medical screening for contraindications ensures safety, while personalised protocol development considers your individual presentation.

Sessions typically require 60-90 minutes in our West London clinic environments. Medical team oversight continues throughout each session, with qualified professionals monitoring the treatment process. Most patients describe minimal discomfort comparable to standard IV therapy—venous access is established in each arm, and blood flows through the EBOO system before returning to circulation.

Initial protocols for Long COVID typically involve 2-3 EBOO sessions spaced 1-2 weeks apart, with frequency adjusted based on symptom severity and individual response. Our medical team monitors your response throughout the treatment course, modifying the approach based on actual outcomes. Regular symptom assessments using standardised scales allow objective progress tracking, while functional capacity improvements provide practical outcome measures.

Who Should Consider EBOO for Long COVID Recovery

Ideal candidates experience persistent Long COVID symptoms lasting 3-6+ months with significant functional impairment affecting work capacity, exercise tolerance, or daily activities. Patients who've tried rest, pacing, and rehabilitation protocols without sufficient improvement represent appropriate candidates, particularly those who've completed basic nutritional support and worked with primary care or Long COVID clinics with limited progress.

Comprehensive health assessment with our qualified medical team precedes any treatment recommendation. Certain medical conditions require additional evaluation, while pregnancy or specific contraindications identified during screening may preclude treatment. Our medical team evaluates suitability individually rather than applying blanket exclusions.

Clinical research demonstrates many patients benefit significantly—the 67-95% response rates provide genuine grounds for optimism. However, individual responses vary, and EBOO supports the recovery process rather than providing instant cures. Best outcomes typically involve comprehensive approaches combining EBOO with appropriate nutrition, graduated activity, stress management, and treatment of comorbid conditions.

EBOO Therapy for Long COVID at IV Drip Clinic London

Our Mayfair clinic provides EBOO therapy under qualified medical team supervision, offering personalised protocols for Long COVID recovery. We combine clinical expertise with state-of-the-art equipment, ensuring medical-grade standards throughout treatment. Our approach includes comprehensive medical assessment, individualised protocols based on symptom presentation, ongoing monitoring and adjustments, and integration with complementary therapies when appropriate.

We offer EBOO therapy at our Mayfair location, providing convenient access for patients across greater London seeking advanced post-viral recovery support. If you're experiencing persistent Long COVID symptoms, our medical consultation explores whether EBOO therapy aligns with your recovery goals, reviewing your medical history, assessing symptom severity, and discussing personalised treatment options.

Frequently Asked Questions About EBOO for Long COVID

Is EBOO therapy safe for Long COVID patients?

EBOO therapy demonstrates a favourable safety profile when administered by qualified medical professionals. Recent clinical research examining systemic ozone therapy for post-COVID asthenia reported zero adverse events across study participants. Our medical team conducts thorough health assessments to identify contraindications before treatment, and all sessions occur under continuous medical supervision using sterile technique and medical-grade equipment.

How many EBOO sessions are needed for Long COVID recovery?

Treatment frequency varies based on symptom severity and individual response. Many patients begin with 2-3 EBOO sessions spaced 1-2 weeks apart, with protocols adjusted based on recovery progress. Clinical research showing significant benefits generally studied structured treatment courses. Our medical team monitors your response and modifies protocols accordingly to optimise outcomes.

What's the difference between EBOO and regular ozone therapy?

EBOO processes your entire blood volume through a dialysis-like filtration system during a single 60-90 minute session, while minor autohemotherapy (MAH) treats small blood volumes of 50-200ml. This comprehensive approach allows every blood cell to receive controlled ozone exposure with precise control over concentration and timing. Clinical evidence showing 67-95% response rates primarily studied EBOO or similar systemic protocols, suggesting advantages for severe post-viral syndromes.

Can EBOO be combined with other Long COVID treatments?

Yes, EBOO often works synergistically with complementary approaches. Many patients combine EBOO with IV vitamin therapy, glutathione IV infusions, or NAD+ therapy for comprehensive cellular support. Our medical team designs integrated protocols considering which combinations best support your specific recovery needs.

Does EBOO therapy work for post-viral fatigue and brain fog?

Clinical research specifically examining EBOO for post-COVID fatigue has shown encouraging results. The 2025 study on systemic ozone therapy demonstrated fatigue scores improved by 74.4% (from 81.9 to 20.5), while cognitive function showed measurable gains on MoCA scale assessments. The Mayo Clinic study reported 82% of Post-COVID Syndrome patients experienced symptom relief, with fatigue and cognitive symptoms among commonly improved manifestations.

How much does EBOO therapy cost for Long COVID treatment?

EBOO therapy represents a premium medical service with treatment costs typically starting from £1,495+ per session. Series pricing often provides better value for patients pursuing structured recovery protocols. The initial medical consultation carries a £450 fee, which applies directly toward treatment costs if you proceed with EBOO therapy. Our medical team discusses recommended treatment frequency and expected total costs during your consultation.

Is EBOO therapy available in London for Long COVID?

Yes, IV Drip Clinic London provides EBOO therapy at our Mayfair location for patients experiencing persistent Long COVID symptoms. Both facilities offer this advanced treatment in sophisticated medical environments with identical clinical standards and medical team oversight.

What are the side effects of EBOO therapy?

EBOO therapy is generally well-tolerated when administered under proper medical supervision. Clinical research has documented minimal adverse events, with recent studies reporting zero complications when protocols follow medical standards. Some patients experience temporary mild fatigue immediately following treatment as the body adjusts to enhanced oxygenation, typically resolving within hours. Our medical team monitors all sessions and provides guidance on what to expect during recovery.

Key Points: EBOO Therapy for Long COVID Recovery

Clinical Evidence for EBOO Therapy

• Mayo Clinic research: 82% of Post-COVID Syndrome patients experienced symptom relief following EBOO treatment
• Medical Gas Research study: 67% of ozone-treated Long COVID patients (100 patients) recovered normal function
• 2025 systemic ozone research: 95% achieved complete/near-complete fatigue resolution with 74.4% improvement in fatigue scores
• Randomised controlled trial (2024): 71% response with ozone therapy vs. 45% control (p=0.0325)
• Zero adverse events reported in recent clinical studies when administered under proper medical protocols
• Glutathione peroxidase levels increased 1.7-fold, validating enhanced antioxidant capacity

EBOO Treatment Approach

• Comprehensive medical assessment identifies appropriate candidates and screens contraindications
• Sessions typically require 60-90 minutes with qualified medical team oversight
• Initial protocols often involve 2-3 sessions spaced 1-2 weeks apart
• Personalised frequency based on symptom severity and individual response patterns
• Can be combined with IV vitamins, NAD+, and glutathione for comprehensive recovery support

Who Benefits Most

• Patients with persistent symptoms 3-6+ months post-infection
• Those experiencing severe fatigue, brain fog, or exercise intolerance
• Individuals who haven't achieved adequate relief from conventional approaches
• Candidates seeking evidence-based advanced therapeutic options with medical oversight

Long COVID presents complex cellular challenges that conventional rest and supplements often fail to address adequately. Clinical evidence demonstrates that EBOO therapy's mechanism of systemic oxygenation and immune modulation supports recovery in many patients experiencing persistent post-viral symptoms.

Research published through 2025 shows encouraging outcomes: a Mayo Clinic study found 82% of Post-COVID Syndrome patients experienced symptom relief, while research demonstrated 67% of ozone-treated Long COVID patients recovered normal function. The most recent 2025 study reported 95% achieved complete or near-complete resolution of post-COVID fatigue, with dramatic improvements in both energy levels and cognitive function.

Our qualified medical team at IV Drip Clinic London provides personalized EBOO protocols tailored to individual Long COVID recovery needs. We conduct comprehensive health assessments, monitor treatment progress, and adjust protocols based on your response—ensuring medical oversight throughout your recovery journey.

If you're experiencing persistent Long COVID symptoms despite trying conventional treatments, our medical consultation explores whether EBOO therapy aligns with your recovery goals. Book a consultation to discuss your symptoms, medical history, and evidence-based treatment options supporting your path toward restored health.